Abstract
Major scientific advances may begin serendipitously. The idea for active compression-decompression cardiopulmonary resuscitation (ACD CPR) came from an anecdotal account of successful resuscitation using a toilet plunger.1Subsequent research supported the concept, as better cardiovascular hemodynamics among animals2,3or humans4-7or better short-term survival among humans8,9was found with ACD CPR compared with standard CPR. One study even suggested that ACD CPR might improve neurological outcomes, as pigs receiving ACD CPR had better cerebral hemodynamics, oxygenation, and metabolism.10 This issue ofThe Journaldescribes a study11of ACD CPR that was terminated by the US Food and Drug Administration (FDA) before completion, primarily because of concerns about informed consent. The project was funded by Ambu International, the maker of the Ambu CardioPump ACD CPR device; there was no federal support. The protocol had been approved by the institutional review board (IRB) of the St
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: JAMA: The Journal of the American Medical Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
