Abstract
Xie Yingjun, Wang Ding and Sun Xiaofang* Author Affiliations 1Key Laboratory for Major Obstetric Diseases of Guangdong Province, China 2Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Experimental Department of Institute of Gynecology and Obstetrics, China 3The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Received: April 01, 2020 | Published: April 27, 2020 Corresponding author: Sun Xiaofang, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China DOI: 10.26717/BJSTR.2020.27.004479
Highlights
Bronchopulmonary dysplasia (BPD), known as Chronic lung disease (CLD), is a chronic lung disease caused by a combination of various factors, impaired alveolar and pulmonary vascular development [1]
Based on the trend of gene signal density under different conditions, we identified a unique set of expression trends
In order to further speculate the potential function of differentially intersecting genes, the correlation between differentially intersecting genes and target genes was analyzed, and it was speculated that apoptosis, Epithelial interstitial transformation (EMT), proliferation, Cell cycle, vascular endothelial growth factor (VEGF) and Notch pathways were important mechanisms of BPD
Summary
Bronchopulmonary dysplasia (BPD), known as Chronic lung disease (CLD), is a chronic lung disease caused by a combination of various factors, impaired alveolar and pulmonary vascular development [1]. Due to various environmental and social factors and prolonged oxygen exposure, prenatal glucocorticoid application, continuous improvement of mechanical ventilation technology etc., especially the widespread application of Pulmonary surfactant (PS), neonatal classic “BPD” “The new type of “BPD” has been transformed, and the survival rate of premature infants has increased. The incidence of BPD has increased, which seriously affects the quality of life and long-term prognosis of preterm infants. The new BPD has become a problem that can’t be ignored in neonatal intensive care unit, which seriously affects the prognosis and quality of life of children
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