Abstract
The Society for Immunotherapy of Cancer, SITC (formerly the International Society for Biological Therapy of Cancer, iSBTc), aims to improve cancer patient outcomes by advancing the science, development and application of biological therapy and immunotherapy. The society and its educational programs have become premier destinations for interaction and innovation in the cancer biologics community. For over a decade, the society has offered the Primer on Tumor Immunology and Biological Therapy of Cancer™ in conjunction with its Annual Scientific Meeting. This report summarizes the 2010 Primer that took place October 1, 2010 in Washington, D.C. as part of the educational offerings associated with the society's 25th anniversary. The target audience was basic and clinical investigators from academia, industry and regulatory agencies, and included clinicians, post-doctoral fellows, students, and allied health professionals. Attendees were provided a review of basic immunology and educated on the current status and most recent advances in tumor immunology and clinical/translational caner immunology. Ten prominent investigators presented on the following topics: innate immunity and inflammation; an overview of adaptive immunity; dendritic cells; tumor microenvironment; regulatory immune cells; immune monitoring; cytokines in cancer immunotherapy; immune modulating antibodies; cancer vaccines; and adoptive T cell therapy. Presentation slides, a Primer webinar and additional program information are available online on the society's website.
Highlights
The Society for Immunotherapy of Cancer, SITC, aims to improve cancer patient outcomes by advancing the science, development and application of biological therapy and immunotherapy
While inflammation is a classic hallmark of cancer, the outcomes following activation of innate immunity and inflammation in cancer can vary
With our much more advanced understanding of molecular and cellular processes involved in generating a productive anti-tumor response, we are able to design cancer vaccine strategies that take into consideration the importance of specific immune cell subsets and tumor antigens, co-stimulation, negative regulation and tumor cell biology
Summary
The Society for Immunotherapy of Cancer, SITC (formerly the International Society for Biological Therapy of Cancer, iSBTc), aims to improve cancer patient outcomes by advancing the science, development and application of biological therapy and immunotherapy. Interferons have many potent immunomodulatory effects, including upregulation of MHC class I and II expression, modulation of T and NK cell cytolytic activity (including antibody dependent cellular cytotoxicity; ADCC), modulation of macrophage and DC function, and potentially alteration of the polarization of T cell subsets within the tumor and in the circulation (e.g., decreasing Tregs and increasing Th1).
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