Abstract
The intracellular distribution of mercury in the liver has been investigated in rats after methoxyethylmercury intoxication. The applied centrifugal technique for the cell fractionation is based on marker enzymes for characterizing the distribution of cellular particles in the fractions. Mercury content is reported in the different fractions. Estimates are presented of the mercury content in mitochondria, in lysosomes and peroximes, and in microsomes (membrane fragments). Some aspects are given of mercury distribution in relation to protein content of fractions, and in relation to thiol group distribution. The usefulness is pointed out, of the method for evaluating different biochemical aspects of mercury intoxication.
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