The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.

J M Biernacka ,T Mushiroda,V Arolt ,Y Ji ,Y L Liu ,S Nonen ,C H Chen ,Daniel K Hall‐Flavin ,K Domschke ,M Kato ,O Kampman ,Shih Jen Tsai ,P Barman ,E Leinonen ,R M Whaley ,B T Baune ,M K Skime ,J C Stingl ,A Batzler ,A Illi ,C J Hong ,J Brockmöller ,M Kubo ,Russ B Altman ,T Kinoshita ,T E Klein ,V Praphanphoj ,Yute Liou ,L Wang ,G Jenkins ,K Sangkuhl ,Richard M Weinshilboum

doi:10.1038/tp.2016.187

Abstract

Correction to: Translational Psychiatry (2015) 5, e553; doi:10.1038/tp.2015.47; published online 21 April 2015 Following publication, the authors identified an error in the meta-analysis of ISPC, AMPS and STAR*D data. The error resulted from a failure to correctly harmonize alleles at some SNPs prior to meta-analyzing results from the three studies.

Highlights

Following publication, the authors identified an error in the meta-analysis of International SSRI Pharmacogenomics Consortium (ISPC), Antidepressant Medication Pharmacogenomics Study (AMPS) and STAR*D data
This error had no impact on the primary analysis, which focused on the ISPC data alone (Table 2, Figure 1), but resulted in several incorrect signals being listed in Table 3
In the Results section, the following sentence should have appeared with the two changes shown in square brackets: ‘ the observed associations are not significant after correction for multiple testing of single-nucleotide polymorphism (SNP) selected for these replication analyses, we observed marginally significant evidence of association of SNP rs11624702 in MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) with response in the ISPC alone (P = 0.061) and [‘and’ should read ‘but not’] in the combined ISPC-AMPS-STAR*D meta-analysis (P = 0.029) [‘0.029’ should read ‘0.36’], with the minor allele being associated with lower odds of response’