Abstract
The interaction between glycophorin, the major sialoglycoprotein of the human erythrocyte membrane, and dipalmitoylphosphatidylcholine (DPPC) has been investigated in mixed monolayers at the air—water interface. Surface pressure—area isotherms have been measured for monolayers covering a range of glycophorin—DPPC molar ratios from 1:1765 to 1:44 at 20°C. The phase transition from the liquid-expanded to liquid-condensed monolayer states characteristic of pure DPPC monolayers is no longer observable in mixed monolayers at glycophorin to DPPC molar ratios in the range 1:355 to 1:44 and the isotherms at low areas per lipid molecule have a lower surface pressure than that calculated for an ideal mixture of the pure components. Analysis of the results indicates that in the range of surface pressure from 15–30 mNm −1, glycophorin withdraws between approximately 1300 to 200 DPPC molecules from participation in chain-melting in the monolayer.
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