Abstract
Osteoarthritis (OA) is a chronic disease affecting the whole joint, which still lacks a disease-modifying treatment. This suggests an incomplete understanding of underlying molecular mechanisms. The Wnt/β-catenin pathway is involved in different pathophysiological processes of OA. Interestingly, both excessive stimulation and suppression of this pathway can contribute to the pathogenesis of OA. microRNAs have been shown to regulate different cellular processes in different diseases, including the metabolic activity of chondrocytes and osteocytes. To bridge these findings, here we attempt to give a conclusive overview of microRNA regulation of the Wnt/β-catenin pathway in bone and cartilage, which may provide insights to advance the development of miRNA-based therapeutics for OA treatment.
Highlights
Osteoarthritis (OA) is one of the most common diseases affecting millions of people worldwide
We summarize the current understanding of how miRNAs influence Wnt/βcatenin signaling in OA development and the ensuing consequences for its pathogenesis and possible treatment
Disheveled was identified as a target of miR-29c-3p, which could further inhibit the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) [59]
Summary
Osteoarthritis (OA) is one of the most common diseases affecting millions of people worldwide. 2. miRNA Biogenesis and Target Prediction microRNAs (miRNAs) are a kind of small non-coding RNAs that are responsible for post-transcriptional regulation of 60% of human genes [4]. Since they were first discovered in 1993, miRNAs have been shown to participate in the modulation of diverse biological processes. It was reported that the human genome might encode more than 1900 miRNAs to modify gene expression [6] Public online websites such as “Targetscan”, “miRWalk”, and “miRDB” provide a prediction of possible targets of miRNAs through the interaction with the 3 UTR of target mRNAs. prediction of the effect of such miRNAs silencing of their mRNA targets is complicated, considering each miRNA has multiple mRNA targets and vice versa. It has been shown that HDAC-4 can be targeted by at least miR-222, miR-140, and miR-365 at the same time [15,16,17]
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