Abstract
Objective: Alcohol use disorder (AUD) is the most common substance use disorder, which may relate to increased impulsivity. A more detailed understanding of the potential moderating factor on association between AUD and impulsivity is likely to have far-reaching effects. This study aims to examine whether the interaction between a genetic variant ZNF804A rs1344706 and alcohol use is related to impulsivity in Chinese Han adult males diagnosed with AUD.Methods: A total of 455 Chinese Han adult males diagnosed with AUD were included in this study. Impulsivity was assessed using Barratt Impulsiveness Scale. Alcohol dependence was measured by Michigan Alcoholism Screening Test. Genomic DNA was extracted from peripheral blood of participants and genotyped.Results: Hierarchical multiple regression yielded a significant interaction between ZNF804A rs1344706 and alcohol use (β = 0.20, p = 0.0237). Then, A region of significance (RoS) test was performed to interpret the interaction effect. Re-parameterized regression models revealed that the interaction between ZNF804A rs1344706 and alcohol problem severity fit to the weak diathesis-stress model (R2 = 0.15, p < 0.0010), indicating that the T allele carriers are more susceptible to alcohol problem severity, jointly contributing to impulsivity.Conclusions: This study, which analyzed a specific gene-environment interaction, demonstrated that carriers of the T allele of ZNF804A rs1344706 may be more susceptible to alcohol problem severity, correlated with higher levels of impulsivity during withdrawal.
Highlights
Alcohol use disorders (AUDs) including the more severe forms of alcohol dependence and withdrawal are the most common substance use disorders, raising severe public concerns worldwide [1, 2]
Barratt Impulsiveness Scale (BIS) scores were positively correlated with Michigan Alcoholism Screening Test (MAST) scores (r = 0.37, p < 0.0010), while the years of education was negatively correlated with both MAST (r = −0.24, p < 0.0010) and BIS scores (r = −0.20, p < 0.0010)
Based on the framework of G×E research on the etiology of AUD-related psycopsychiatrical issues, this study examined the interaction between ZNF804a rs1344706 and alcohol problem severity during withdrawal on impulsivity in Han Chinese patients diagnosed with alcohol dependence
Summary
Alcohol use disorders (AUDs) including the more severe forms of alcohol dependence and withdrawal are the most common substance use disorders, raising severe public concerns worldwide [1, 2]. In mainland China, the prevalence of AUDs for males reached 10.1% [4], which leads to a high burden of physical conditions as well as psychological disorders. AUDs can be characterized as an adaptive state formed by repeated alcohol use, which can lead to withdrawal upon cessation. The reward and stress systems result in continued use in relation to long-term neurocognitive changes. The neurocognitive consequences of AUDs include impairments in memory, attention, and executive function [5,6,7], which may result in risky decision-making and lack of planning or focusing, culminated in an increase in impulsivity. A more detailed understanding of the relationship between AUDs and impulsivity is likely to have far-reaching effects in terms of prevention and treatment
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