The injection on myocardial protection and prognosis of acute organophosphorus pesticide with Salvia miltiorrhiza

Abstract

Objective To investigate the effects of hemodynamic,prognostic effect and myocardial protection of Salvia injection on patients with acute organophosphorus pesticide poisoning. Methods 68 cases of patients with acute organophosphate were divided into observation group（n=34）and control group（n=34） from January 2012 to December 2013.The control group were given with atropine detoxification （dose：5-10mg）, Tiopronin （0.2 g/d, 1 times/d） liver treatment, Pioneer will（2 g/second,1/d）.The observed group received the foundation treatment and Salvia injection（30ml, 1/d）, 7d course of treatment. The myocardial enzymes and hemodynamic parameters of two groups were observed before and after treatment. Results The survival rate and died rate of observation group were 94.12%（32 cases ）, 5.88%（2 cases ）. The survival rate and died rate of control group were 79.41%（27cases ）and 20.59%（7cases）. The survival rate and died rate of two groups were significant difference （χ2=5.123, P〈0.05）. The myocardial enzymes （AST, CK, CK-MB, LDH, HBDH） of observation groupafter 2d each index[were（58.6±22.7）U/L, （412.6±156.9）U/L, （78.6±＆amp;nbsp;35.2）U/L, （489.3 ± 112.3）U/L, （412.8 ± 259.6）U/L] and blood rheology （ESR, FIB, LBV, HBV）each index[were（14.36±4.19） mm/h before , （259.3±23.14）g/L, （7.17±1.12）mPa？s, （4.12±0.81）mPa？s]were lower than in the same group therapy [myocardial enzymes indexes were （131.3±32.5）U/L, （1324.5± 345.2）U/L, （187.5 ± 72.2）U/L, （914.5 ± 312.2）U/L, （812.3 ± 312.2）U/L; hemorheology indexes were （23.29±3.49）mm/h, （389.57±34.24） g/L, （10.4±1.3）mPa？s, （6.3±1.2）mPa？s]. 5 d after treatment control group myocardial enzymes（AST, CK, CK-MB, LDH, HBDH）each index[were（85.3±22.8）U/L, （486.3± 78.9）U/L, （67.8±11.2）U/L, （542.3±78.6）U/L, （225.9±112.4）U/L]and hemorheology indexes[were（17.7± 4.6）mm/h, （289.4±32.5）g/L, （8.9±1.2）mPa？s, （5.6±1.3）mPa？s] was significantly lower than in the same group before treatment[myocardial enzymes indexes were（128.3±29.3）U/L, （1298.6±329.4）U/L, （182.6± 70.6）U/L, （902.3±286.3）U/L, （803.6±293.6）U/L;hemorheology indexes were （23.9±3.5）mm/h, （382.6± 32.5）g/L, （10.3±1.1）mPa？s, （6.2±1.1）mPa？s, P〈0.05]. Conclusion Salvia injection can effectively improve the hemodynamic indicators of acute organophosphorus pesticide poisoning patients , reduce myocardial damage, promote patient prognosis. Key words: Salvia injection; Acute organophosphorus; Myocardium; Hemodynamic