Abstract
Understanding the inhibitory mechanism of cryoprotective agent on ice growth is essential for preventing the cryoinjury of vivo biological tissue and for the bioactive protection of protein medicine in cryopreservation processes. The crystallization growth process of (0 2 0) crystal face of orthorhombic ice in l-lysine hydrochloride aqueous solutions was researched by molecular dynamic. The results indicated that l-lysine ion has a competitive adsorption on the lattice sites of ice interface with water molecule. The binding carboxyl (COO−) and flexible l-lysine chain can disrupt the periodic continuous growth of ice. The free l-lysine ion and chlorine anion (Cl−) inhibit the diffusion of water molecules which makes ice crystals difficult to grow. This final results proved that l-lysine ion can inhibit ice crystal growth in both aqueous and crystalline phases.
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