Abstract
Background. We have previously shown using sealed, non-perfused, ducts that Substance P (SP) inhibits HCO3-secretion by inhibiting Cl-dependant HCO3-efflux on the luminal membrane of the duct cell (Hegyi et al. Am J Physiol Cell Physiol 285: C268-C276, 2003). However, in that study we had no direct evidence that SP affected a luminal anion exchanger. To address this issue we examined the effects of luminal H2DIDS on the inhibitory effect of SP in microperfused ducts.
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