Abstract
The inhibitory effects of eight neuroleptics (six butyrophenones and two phenothiazines) on the penetration of noradrenaline from cytoplasm into intracellular granules in rat brain were investigated. Four of them are potent inhibitors of this phenomenon. The results suggest that, from a physico-chemical point of view, there are two classes of neuroleptics, class I acting primarily at the intracellular granular membrane level, class II primarily at the whole cell membrane level.
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