Abstract
A sensitive method has been developed which allows estimation of pseudoephedrine in plasma at drug concentrations as low as 0.05 fLg per milliliter, making possible, for the first time, the measurement of pseudoephedrine in human plasma. In 3 normal volunteers, the plasma ty, of pseudoephedrine was 5.2,7.6, and 8.0 hours, respectively. When urinary pR was decreased by the administration of NR,Cl, the plasma ty, of pseudoephedrine decreased markedly. In contrast, when urinary pR was increased by the ingestion of NaRCOs, the plasma ty, of pseudoephedrine increased.
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