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The influence of SLC22A3 rs543159 and rs1317652 genetic variants on metformin therapeutic efficacy in newly diagnosed patients with type 2 diabetes mellitus: 25weeks follow-up study.

Publication Date May 20, 2022

Abstract

Among anti-diabetic medications, metformin has been proven to be the preferred initial pharmacologic agent for type 2 diabetes mellitus (T2DM) treatment. Despite its safety and efficacy, the response to metformin varies between individuals. Genetic variations, especially within genes involved in pharmacokinetics and pharmacodynamics of metformin (e.g SLC22A3), have been suggested to be responsible for the observed inter-individual differences. By considering the undeniable role of organic cation transporter 3 in hepatic uptake of metformin, this study was aimed to investigate the association of rs543159 and rs1317652 variants in SLC22A3 gene with response to metformin monotherapy in newly diagnosed patients with T2DM. The study included 200 T2DM patients who received metformin monotherapy for 25weeks. The patients were classified into 2 groups according to their HbA1c values: the responders (reduction in HbA1c levels by at least 1% after 25weeks treatment with metformin) and non-responders (less than 1% reduction in HbA1c levels after 25weeks treatment with metformin). We used tetra ARMS-PCR method to determine genotypes of the target variants. For the rs543159, CA and AA genotypes were more frequent in responders as compared to non-responders (OR=2.48; 95% CI=1.28-4.78, P-value=0.0057) under the dominant model. In case of rs1317652 CC and CT genotypes were more frequent in metformin responders as compared to non-responder group (OR=2.49; 95% CI=1.32-4.70, P-value=0.0043) under the dominant model. Parameters such as fasting ...

Concepts
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HbA1c Levels
Type 2 Diabetes Mellitus
Reduction In HbA1c Levels
Role Of Organic Cation Transporter
SLC22A3 Gene
Metformin Monotherapy
Baseline HbA1c Values
Pharmacodynamics Of Metformin
Type 2 Diabetes Mellitus Patients
Dominant Model

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