Abstract
Objective To observe the combined effects of puerarin injection and irbesartan on congestive heartfailure(CHF) in dogs with ventricula fibrous ventricular rapid pacing heart failure.Methods 21 healthy mongrel dogs were randomly divided into normal control group,CI-IF model group and the TMP treated group.CHF was established by right ventricular pacing model of canine.Butst was used to evoke atrial fibrillation (atrial fibrill;tripn,LVEF).Echocardiography was used to detect left ventricular ejection fraction in dogs (Left ventricular ejection fraction,LVEF).Mallory's three-color staining was used to detect the degree of atrial fiber.The level of plasma angiotensin 1,aldosterone concentration,m-type forelimb of the original N-terminal peptide (amino-terllllrlal1 ～ eptldcoftype Ⅲ procollagen,P Ⅲ NP),laminin (1 alTlmln,IN),and hyaluronic acid (hyaltlronlcacid,HA)was detected with radioimmunoassay.Results The LVEF of CHF model group decreased significantly compared with the control group(P ＜0.01).AF incidence ,the incidence of persistent AF and AF duration were significantly increased when compared with the control group(P ＜ 0.01).Left atrial fibrosis were also significantly increased in CHF model group than normal control group (P ＜ 0.01).AF duration was positively correlated with the degree of left atrial fiber (r = 0.84,P = 0.018).plasma angiotensin Ⅱ ,aldosterone,and serurn P Ⅲ NP,HA levels were significantly higher than normal control group(P ＜0.05 or P ＜0.01).There was no statistical difference in LN.Plasma angiotensin Ⅱ and aldosterone levels showed a close positive correlation(r =0.759 ,P =0.182).There is significant improvement in LVEF in treatment group when compared with model group(P ＜ 0.05).The incidence of persistent AF was significantly lower in treated group when compared with CHF model(P ＜ 0.05).The left atrial fibrosis was significantly reduced in treated group when compared with CHF(P ＜ 0.01).Conclusion Puerarin injection combined with irbesartan can reduce II-IF degree of atrial fiber,which may be one of the mechanisms of the reduction of the incidence and duration of CHF and AF. Key words: Puerarin injection; Irbesartan; Joint; Heart failure; Congestive; Atrial fibrillation
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