Abstract
Periodontal pathologies are highly widespread throughout the world. Epidemiological studies have shown that as much as 1% of the population is suffering from periodontal disease. In recent years, there has been a growing number of studies linking these diseases with autoimmune diseases, especially with rheumatoid arthritis. This literature review evaluates changes in the relationship between periodontal pathologies caused by the bacterium Porphyromonas gingivalis and rheumatoid arthritis. The systematic review of the literature was performed according to the PRISMA analysis protocol. The review was performed with articles from the PubMed database. Searched articles were not older than 5 years. Only full texts and research performed with people were selected. A total of 56 results were received. A review and analysis of their full texts have been carried out and 10 articles were selected according to the established criteria. They were analyzed and results were presented. The results obtained from the literature were based on the influence of Porphyromonas gingivalis on the pathogenesis of rheumatoid arthritis. In the literature, the activity of this bacterium is explained by the analysis of its enzyme peptidylarginine deiminase and its principle of action. Studies have also been found to prove the presence of Porphyromonas gingivalis not only in the oral cavity but its DNA is also found in synovial fluid and plasma. In the researched articles, direct links between Porphyromonas gingivalis and rheumatoid arthritis have led doctors to draw attention to patients' oral hygiene and the condition of parodentium, as this may be the cause of autoimmune lesions. Treatment of periodontal disease will not only help maintain a healthy oral cavity but prevent the spread of bacteria to the surrounding tissues.
Highlights
BackgroundRheumatoid arthritis (RA) is an autoimmune disease, which is very common and it affects about 1% of the total population [1]
The results obtained from 10 different authors have shown that PPADs produced by Porphyromonas gingivalis bacterium have a significant influence on the pathogenesis of rheumatoid arthritis
Literature reviewing the relationship between rheumatoid arthritis and periodontal disease has been reviewed and analyzed
Summary
Rheumatoid arthritis (RA) is an autoimmune disease, which is very common and it affects about 1% of the total population [1]. Okada et al performed a study, analyzing the IgG levels on Porphyromonas gingivalis by ELISA showed that patients with RA had a much higher antiPorphyromonas gingivalis and anti-cyclical citrullinated peptide antibody levels than the control group [17]. Okada et al showed that patients with RA had much higher levels of anti-Porphyromonas gingivalis and anti-cyclic citrullinated peptide antibodies than the control group [17] All of these studies support the pathological changes caused by Porphyromonas gingivalis and the presence of rheumatoid arthritis as related pathologies. With the weakening body's immunity and resistance, it becomes more susceptible to bacteria and infections, such as Porphyromonas gingivalis, which are found in people‘s mouths more actively This bacterium produces an enzyme called peptidylarginine deiminase (PAD, which is identified in the literature of this bacterium, and may be called PPAD). During Arvikar et al research, the results showed, that a subset of early RA patients had positive Pg antibody responses [11]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
