Abstract
the total sample consisted of 505 articles, from which 6 studies were eligible after a qualitative analysis. From the drugs assessed, paracetamol was unanimous for not interfering within orthodontic movement when compared to the control group. However, drugs such as aspirin, ibuprofen, sodium diclofenac, and selective cyclooxygenase-2 inhibitors caused a reduction in tooth movement when compared to the control group. paracetamol could be considered the drug of choice for pain relief because it interferes less within tooth movement.
Highlights
Tooth movement is achieved through mechanical forces provided by orthodontic appliances
Considering the current lack of scientific evidence towards the selection of drugs for pain control in orthodontic patients and the increasing need to achieve levels of excellence in orthodontic treatment, the present study aims to perform a systematic literature review to determine if there is a non-steroidal anti-inflammatory drug (NSAID) that interferes less within tooth movement
Focused Question: The present systematic review was performed aiming to answer the following question: “Among non-steroidal anti-inflammatory drugs effective for pain control, is there one that interferes less within tooth movement?”
Summary
Tooth movement is achieved through mechanical forces provided by orthodontic appliances. An essential inflammatory process occurs changing the local vascularization and increasing the blood flow in the PDL (Krishnan and Davidovitch 2006) Along with this process, cytokines, growth factors, transformation factors, and neurotransmitters are released (Bollen et al 2008), creating a proper environment for bone remodeling. Cytokines, growth factors, transformation factors, and neurotransmitters are released (Bollen et al 2008), creating a proper environment for bone remodeling In this environment, bone resorption is observed on the compression side of the PDL fibers, while bone formation is observed on the tension side (Garlet et al 2008). There is a higher bone deposition instead of resorption (Takayanagi 2012)
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