Abstract
Pregnant women with obesity (body mass index, BMI ≥ 30 kg/m2) are more likely to experience prolonged labor and their risk of cesarean is double, compared with those of normal weight (BMI < 25 kg/m2). Oxytocin and prostaglandin F (PGF) are important mediators of myometrial contractility, and COX-2 is downstream of oxytocin signaling and crucial for production of prostaglandins. Our objective was to compare myometrial gene and protein expression of oxytocin and PGF receptors and their downstream signaling in obese and normal weight pregnant women at term.
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