Abstract
The intercellular lipid multilayers of stratum corneum, the outermost layer of mammalian skin, is generally accepted as the rate determining pathway of transmembrane diffusion for lipophilic solutes. The short chain alcohols, iso-propanol, n-propanol and n-butanol, are known to enhance permeation through the stratum corneum at low concentrations. The effects of these alcohols, at concentrations giving equivalent penetration enhancement, on the stratum corneum lipid alkyl chain packing, mobil- ity and conformational order as measured by Fourier transform infrared (FTIR) spectroscopy have been investigated. Reference is made to studies of model DSPC/DSPA phospholipid multilamellar vesicles in the presence of the alcohols. Iso-propanol and n-butanol do not alter the stratum corneum lipid interchain interactions and gel-gel phase transition. n-Butanol is shown to increase the lipid chain freedom of motion above 45 ° C. However, only n-propanol appears to alter the stratum corneum lipid gel to liquid-crystalline phase transition. In the densely packed gel state (below 45°C), n-butanol was demonstrated to decrease the alkyl chain freedom of motion.
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