The influence of irrigation of bladder to the recurrence of bladder tumors after surgery of upper urinary tract tumors

Abstract

Objectives To investigate the influence of irrigation of bladder to the recurrence of bladder tumors after surgery of upper urinary tract transitional cell carcinoma of the upper urinary tract.Methods The 96 patients who underwent total nephroureterectomy for clinically localized transitional celt carcinoma of the upper urina - rv trace.All of them were followed up and their data were retrospectively analyzed.Results After nephmureteree - tomy and resoction of partial bladder wall,the bladder transitional cell carcinoma (TCC) recurrence rate Was 34.4% (11/32)in patient who had rejected adoption intravesical chemotherapy,being obviously higher than patient who a - doption intravesical chemotherapy 18.8%(12/64,P 0.05).The bladder TCC recurrence rates in patient whose ureter had been ligated before the kidney Was dissociated lower than whose ureter had not been ligated. Ahhoush the difference was not statistically significant the resuIt demonstrated a strong trend that this surgery method may contribute to prevent the bladder TCC recurrence.Conclusios The prophylactic intravesical chemotherapy is a useful approach for reducing the recurrence of bladder TCC afier surgery of upper urinary tract TCC.A possible reduction of bladder TCC - risk by intraoperative ureteric ligation and/or peri - operative topical intravesical chemotherapy instillation are justified. Key words: Kidney Neoplasms; Ureteral Ueoplasms; Bladder Neoplasms