Abstract
Finding the cause of acne is a key aspect to improve skin appearance and eliminating the problem completely. Due to the multitude of origins and their coexistence, acne treatment is in most cases long-lasting and cannot be limited to one action. Increasing importance in the occurrence and course of acne vulgaris is paid to the high glycemic index of consumed food and insulin-like growth factor (IGF-1). IGF-1 receptors are located on keratinocytes and in acne patients their elevated expression in the epidermis and sebaceous glands is noticed. High levels of IGF-1 are observed in adolescents, as well as in adult women struggling with late acne affecting people over 30 (Acne tarda). It is suspected that it is not androgens, but IGF-1, that is the key element in the appearance and course of Acne vulgaris.
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