Abstract
The potential local toxicity to the nasal mucosa of insulin, various absorption promoters and vehicles has been tested in the frog palate model. The influence on mucociliary transport rate was used as an estimate of toxicity. Full inhibition of this rate was observed with 1% l-α-lysophosphatidylcholine, 1% polyoxyethylene-9-lauryl ether, 1% sodium deoxycholate and 1% sodium dihydrotaurofusidate, whereas 1% sodium glycocholate and 1% didecanoyl- l-α-phosphatidylcholine had no effect. 0.1% sodium dihydrotaurofusidate increased the mucociliary transport rate and the insulin formulation Novolin ® reduced the rate slightly, but these latter effects were always reversible.
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