Abstract
ABSTRACTThe co-occurrence of multiple pathologies in the pelvic viscera in the same patient, such as, irritable bowel syndrome and interstitial cystitis, indicates the complexity of viscero-visceral interactions and the necessity to study these interactions under multiple pathological conditions. In the present study, the effect of distal colon irritation (DCI) on the urinary bladder interaction with distal esophagus distention (DED), distal colon distention (DCD), and electrical stimulation of the abdominal branches of vagus nerve (abd-vagus) were investigated using cystometry parameters. The DCI significantly decreased the intercontraction time (ICT) by decreasing the storage time (ST); nonetheless, DED and Abd-vagus were still able to significantly decrease the ICT and ST following DCI. However, DCD had no effect on ICT following the DCI. The DCI, also, significantly decreased the Intravesical pressure amplitude (P-amplitude) by increasing the resting pressure (RP). Although DED has no effect on the P-amplitude, both in the intact and the irritated animals, the abd-vagus significantly increased the P-amplitude following DCI by increasing the maximum pressure (MP). In the contrary, 3mL DCD significantly increased the P-amplitude by increasing the MP and lost that effect following the DCI. Concerning the pressure threshold (PT), none of the stimuli had any significant changes in the intact animals. However, DCI significantly decreased the PT, also, the abd-vagus and 3mL DCD significantly decreased the PT. The results of this study indicate that chemical irritation of colon complicates the effects of mechanical irritation of esophagus and colon on urinary bladder function.
Highlights
Due to viscero-visceral interactions, many inflammatory conditions have manifestations affecting the pathological organ but extends onto other viscera within the same vicinity or even further away
Cystometry recordings were done for 10 minutes with esophagus distention, followed by 10 minutes recordings without esophagus distention
Cystometry recordings were done for 30 minutes with distal colon distentions (10 minutes for each increment of distal colon distentions; 1mL, 2mL and 3mL)
Summary
Due to viscero-visceral interactions, many inflammatory conditions have manifestations affecting the pathological organ but extends onto other viscera within the same vicinity or even further away. Chronic pelvic pain could be attributed to many conditions affecting urinary bladder/interstitial cystitis, gastrointestinal tract/irritable bowel syndrome, prostate gland/prostatitis or any other pelvic organ pathology [1]. Colon inflammation in rats was shown to increase urinary bladder frequency [2]. Patients ibju | effect of colon irritation on bladder interactions with irritable bowel syndrome showed symptoms of urinary bladder dysfunction, such as, an increase in urination frequency, as well as an increase in residual volume [4]. Patients with interstitial cystitis showed higher incidence of irritable bowel syndrome and other systemic diseases compared to controls [5]
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Schedule a callMore From: International braz j urol : official journal of the Brazilian Society of Urology
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