Abstract
Cobalt was studied in vivo and in vitro with respect to its effect on adrenocortical output. In the intact dog, cobalt produced an increase in adrenal effluent corticoid concentration and minute corticoid output. This increment in cortical output was partially masked by concomitant changes in adrenal venous blood flow (decreased) and hematocrit (increased). The action of exogenous ACTH was unaffected by administration of 30 μM/kg of cobalt, but was inhibited when the dose of cobalt was doubled. Cobalt, in the amounts of 10 −8 and 10 −5 micromoles, stimulated corticoid production in vitro while one micromole caused inhibition. The latter concentration of cobalt also inhibited the in vitro stimulatory action of ACTH, glucose-6-phosphate (G-6-P) plus TPN and reduced TPN. The response to ACTH was enhanced in the presence of 10 −8 micromoles of cobalt. These findings suggest that cobalt exerts a direct action on the adrenal cortex of the dog.
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