Abstract

1. White Leghorn hens, 14–29 weeks old, were surgically fitted with cannulas for collecting pancreatic and bilary secretions, and a jugular cannula for continuous infusion of either cholecystokinin (CCK), vasoactive intestinal peptide (VIP), or secretin. 2. As compared to secretory levels during saline infusion, CCK significantly stimulated biliary flow and biliverdin concentration in bile; VIP significantly depressed biliverdin concentration but enhanced bicarbonate secretion in both pancreatic and biliary secretions, and also increased total pancreatic flow. Secretin depressed biliary flow and increased pancreatic bicarbonate release. 3. The principal hormonal regulator of biliary secretion appears to be CCK, and that of pancreatic secretion to be VIP.

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