Abstract
In adrenalectomized animals, a single administration of triiodothyronine triggers off an induction of hepatic mitochondrial α-glycerophosphate dehydrogenase ( L-glycero-3-phosphate: cytochrome c oxidoreductase, EC 1.1.99.5) comparable to that seen in intact animals. A qualitatively similar effect is observed in adrenalectomized animals supplemented with cortisone but, in this case, the extent of the induction by triiodothyronine is diminished. The administration of cortisone counteracts the stimulatory effect of adrenalectomy per se on α-glycerophosphate dehydrogenase levels but has no effect on the basal levels of this enzyme activity in intact animals. Adrenalectomy has a more pronounced stimulatory effect upon α-glycerophosphate dehydrogenase levels of thyroidectomized than of intact animals. Puromycin and actinomycin D inhibit the induction of α-glycerophosphate dehydrogenase by triiodothyronine in thyroidectomized animals as effectively as in intact animals.
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