Abstract
The in vivo synthesis of rRNA and tRNA within the proximal region of the rat vagus nerve, up to and including the crush site, rapidly increased following vagotomy. Synthesis was maximal at 2 days post-crush when a 15-fold increase in rRNA was observed. This increase was localized to the region 2–3 mm either side of the crush site. Apparent DNA synthesis also appeared substantially elevated at 2, 4 and 7 days post-crush. These results are consistent with a Schwann cell hypertrophy at the site of injury which facilitates removal of axonal debri and myelin and provides structures to receive new axonal sprouts.
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