Abstract
To investigate the improving effect of 2-methacryloyloxyethy1 phosphoryl-choline (MPC) on skin barrier damage, skin irritation animal model was produced by the application of sodium dodecyl sulfate (SDS) to the backs of hairless mice for 1 week. And experimental materials were applied topically for 1 week during the same period. At the 7th day of experiment, positive control (PC, sodium hyaluronate 1%) and experimental groups [E1, C/L Poly (AA-Co-MPC 3w%) 0.5%; E2, C/L Poly (AA-Co-MPC 5w%) 0.5%, E3, C/L Poly (AA-Co-MPC 10w%) 0.5%] had significantly (p⁄0.05) lower values of both skin erythema index and water capacity than the vehicle control [VC, C/L Poly (AA) 0.5%] group. E2 and E3 groups had significantly (p⁄0.05) lower values of transepidermal water loss than the VC group. The appearance of mast cells in dermal and subcutaneous layers was remarkably reduced in E1, E2 and E3 groups compared to the VC group. It is found that MPC is effective in skin barrier damage in hairless mouse.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
