Abstract
Even though coffee is not considered to be responsible for development of peptic ulcer, it may, however, prolong its healing by increasing acidity of gastric content. In our former work we observed a profound increase in sucrose permeability (above normal values) in healthy volunteers regularly drinking coffee for years. In literature, many factors affecting sucrose permeability have been described so far. None of them, however, studied the effect of coffee. 10 young asymptomatic habitual coffee drinkers were included in the study. The probands underwent SaLM test twice--first time without coffee restriction and second time after 48-hour coffee abstinence. The ingested SaLM solution comprised sucrose (25.0 g), lactulose (10.0 g), mannitol (2.0 g), xylose (2.0 g) and water (up to 100 ml). Urine was collected for five hours and the samples were analysed using gas chromatography. Results were compared with those of 8 young healthy volunteers not drinking coffee. Permeability for sucrose was significantly higher in the group of habitual coffee drinkers in comparison with non-coffee drinkers (p < 0.01). After 48-hour coffee abstinence sucrose excretion decreased significantly (p < 0.05) to a level not differing from that of non-coffee drinkers (p = 0.54). Our results indicate that coffee may damage gastroduodenal mucosa in habitual coffee drinkers. In a time period of 48 hours the gastroduodenal mucosa is capable of a significant regeneration.
Highlights
Subjects, materials and methodsEven though coffee is not considered to be responsible for development of peptic ulcer, it may prolong its healing by increasing acidity of gastric contents [4]
The normal value obtained from healthy probands not drinking coffee by adding two standard deviations to mean supports the value found by ROC (Receiver operating characteristic) analysis using volunteers with no respect to habitual coffee drinking [3]
Our results indicate that coffee may damage gastroduodenal mucosa in habitual coffee drinkers
Summary
Even though coffee is not considered to be responsible for development of peptic ulcer, it may prolong its healing by increasing acidity of gastric contents [4]. After night fasting the probands provided a urine sample from the second morning urine, since the first morning urine might contain adulterants capable of interferring with disaccharides during laboratory investigations. This urine was considered a control sample. The results were compared with 8 young healthy nonsmokers not drinking coffee (5 males and 3 females, age 22.1 ± 1.8, range 19–25). This group was considered a control group.
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