Abstract
Aim . Arcuate nucleus (AN) of the hypothalamus is one of the integrative centers responsible for energy metabolism in mammals. Reaction of the arcuatus nucleus of white rats on the toxic stress caused by introduction of cadmium chloride in the conditions of natural illumination, light and dark deprivations was studied. Methods. The toxicant was entered per os at a dose of 2 mg on 100 g of body weight a daily for 15 days after one month of adaptation to an the artificial photomode. Synthetic activity was estimated a method nucleoli volumes’ measurement on hematoxylin and eosin sections of the hypothalamus. Results. As light and dark deprivations led to the reduction of the nucleoli volumes of AN at animals of both sexes. Salt of cadmium in the conditions of natural illumination has caused reduction of the nucleoli sizes, but only in males. On the contrary, on the background of dark deprivation cadmium chloride led to decrease in activity of AN only in females. Light deprivation promoted increase in synthetic activity of AN neurocytes under the influence of cadmium salt in males, but did not change that in females. Conclusion. The impact of toxic stress induced by administration of cadmium chloride on the hypothalamic centre responsible for energy metabolism of the organism depends on light intensity and sex of the animal. Inhibition of the synthetic activity of AN by cadmium chloride in natural lighting is more pronounced in males, and in the dark of deprivation it is more pronounced in females.
Highlights
Наличие циркадианной функциональ- кий фотопериод (8 ч освещения) была выше, ной активности различных физиологических чем в длинный (16ч) [4]
Зе экзогенно–конституционального ожирения // Рус- Gender related differences in kidney injury induced by ский медицинский журнал. 2009
Zaitsev is responsible for the correction of the manuscript and the translation before submitting the article
Summary
Изучена реакция АЯ белых крыс на токсический стресс, вызванный введением хлорида кадмия в условиях естественного освещения, световой и темновой деприваций. Соль кадмия в условиях естественного освещения вызвала уменьшение размеров нуклеол, но только у самцов. На фоне темновой депривации хлорид кадмия приводил к снижению активности АЯ только у самок. Световая депривация способствовала увеличению синтетической активности нейроцитов АЯ под действием соли кадмия у самцов, но не изменяла таковую у самок. Вызванного введением хлорида кадмия, на гипоталамический центр, ответственный за энергетический метаболизм организма, зависит от режима освещенности и пола животного. Угнетение синтетической деятельности АЯ хлоридом кадмия при естественном освещении более выражено у самцов, а при темновой депривации – у самок. Влияние токсического стресса на морфофункциональное состояние аркуатного ядра гипоталамуса в условиях измененного режима освещенности // Юг России: экология, развитие.
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