Abstract
Direct compression remains one of the most favourable methods available to produce tablet compacts due to its simplicity, efficiency and cost effectiveness however, the technique still remains unsuitable for the majority of formulations due to materials exhibiting poor physical properties such as inadequate compressibility and deformation mechanisms. Whereas crystallo-co-spray drying of various blends has shown to improve the tabletting properties of poorly processable materials, the role of the solvent feed composition in altering the soluble fraction ratio of the excipient to the drug in a crystallo-co-spray dried agglomerate is not well understood. The aim of this work was to investigate the role of the soluble fraction of a drug (paracetamol) and an excipient (α-lactose monohydrate) on the tabletting properties of their crystallo-co-spray dried agglomerates produced via co-spray drying using various inlet feed solvent compositions in order to vary the soluble fraction of the excipient in the feed. It was found that an increase in excipient soluble fraction in the inlet feed resulted in a greater degree of intimate mixing in the final spray dried powder blend, which in turn led to an improvement in tabletting properties of the poorly processable drug.
Highlights
Direct compression is regarded as one of the most promising approaches to tablet manufacture due to its lack of laborious steps such as those involved in wet and dry granulation (Chauhan et al, 2017)
We have shown recently that in crystallo-co spray drying the inlet feed composition had the most pronounced impact on the morphology of the agglomerates (McDonagh and Tajber, 2020)
It was anticipated that the variability in the degree of intimate mixing following a crystallo-cospray drying process may affect the downstream processing, in particular tabletting, of the materials obtained
Summary
Direct compression is regarded as one of the most promising approaches to tablet manufacture due to its lack of laborious steps such as those involved in wet and dry granulation (Chauhan et al, 2017). It is a process in which tablets are compressed directly from powder blends without any prior pre-treatment meaning that it is simple, quick and cost-effective (Gohel and Jogani, 2005; Shangraw, 1993). The concept of crystallo-co-agglomeration has successfully been translated to spray drying to produce crystalline agglomerates of a drug and an excipient with the exception that instead of a bridging liquid being required for agglomerate formation, the diffusion of the components of an atomised droplet towards the centre of the droplet was instead utilised (McDonagh and Tajber, 2020)
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