The Impact of Targeted Interventions Aimed to Improve Quality of Life in Patients Receiving Home Parental Nutrition - A Systematic Literature Review.

Abstract

Home Parenteral Nutrition (HPN) is a specialised therapy offered to people suffering from intestinal failure. Underlying disease, HPN complications and limitations of HPN can significantly impact a person's Quality-of-Life (QOL). The aim of this review was to evaluate the evidence on existing non-surgical/non-pharmacological interventions aimed at improving QOL, clinical, patient-reported and economic outcomes for patients receiving parenteral nutrition therapy at home across adult and paediatric settings. Online databases Medline (Ovid), Embase, and Cinahl were searched to identify studies published between 1937 to 31st March 2022. Identified studies were appraised using the Cochrane Collaboration risk of bias tool and Grading of Recommendations Assessment, Development and Evaluation (GRADE) assessment. Nine studies were included in this review. Interventions were focused on education (4), telemedicine (2), preparation of infusion mixtures (1), Mindfulness-Based Cognitive Therapy (1) and a multi-modal approach (1). Only one study measured QOL before and after the intervention using a validated QOL tool. All studies were assessed at either some, high or critical risk of bias, resulting in low, or very low-quality evidence for the interventions evaluated. The findings from this review highlight the lack of high-quality non-surgical/non-pharmacological studies seeking to improve QOL for people on HPN. As the majority of people receiving HPN are not eligible for surgical or pharmaceutical treatments, higher quality research using clinical trial design, and research focused on improving QOL is needed to inform healthcare managers about the effectiveness (and value) of alternative service delivery models for this vulnerable patient group. This article is protected by copyright. All rights reserved.