Abstract
BackgroundOveractive bladder (OAB) can frequently exert a negative effect on female sexual function. Mirabegron, a β3 receptor agonist, improves OAB symptoms, but there are very few information about its role on female sexual dysfunction (FSD). Aim of the study was to assess the impact of Mirabegron on FSD in women affected by OAB.MethodsFifty sexually active women suffering from idiopathic OAB were included in the study. Patients were assessed by means of a urogynecologic physical examination and were asked to complete the 3-day voiding diary, the International Consultation on Incontinence Questionnaire- Short Form (ICIQ-SF), the Female Sexual Function Index (FSFI) questionnaire and VAS, before and 12 weeks after treatment with Mirabegron. In addition, at the same time points, patients underwent uroflowmetry with the measurement of post- void residual volume (PVR).ResultsAt baseline all patients were affected by OAB symptoms, with 49/50 patients (98%) presenting with FSD. At 12- weeks follow- up, OAB symptoms improved significantly in all patients, with 59.5% of subjects achieving a complete urinary continence. FSFI Total Score significantly improved in 42/50 patients (84%) from 18.9 ± 4.3 to 21.8 ± 4.5 (p < 0.0001). Sixteen cases (32%) presented with no FSD. Also mean ± SD scores of ICIQ-SF and VAS significantly improved (from 17.1 ± 5 to 7.9 ± 4.8 and from 3.9 ± 1.2 to 6.9 ± 1.2 respectively, p < 0.000).ConclusionsMirabegron not only is able to control urinary symptoms in women with OAB, but also induces a significant improvement in their sexual life.
Highlights
Overactive bladder (OAB) can frequently exert a negative effect on female sexual function
Brief summary Women with OAB may suffer from sexual dysfunction
This study shows that Mirabegron is able to improve female sexual function
Summary
Overactive bladder (OAB) can frequently exert a negative effect on female sexual function. Mirabegron, a β3 receptor agonist, improves OAB symptoms, but there are very few information about its role on female sexual dysfunction (FSD). Aim of the study was to assess the impact of Mirabegron on FSD in women affected by OAB. One of previous studies demonstrated a great deterioration in sexual Quality of Life (QoL) in women with OAB than in those with only urinary incontinence. It has been demonstrated that the improvement in OAB symptoms, as induced by a pharmacological treatment, can determine an amelioration in female sexual life [5]. Aim of the study was to determine whether Mirabegron, used as a treatment for OAB symptoms, can have a positive effects on Female Sexual Dysfunction (FSD) and to identify possible relationships between the improvement in urinary symptoms and changes in female sexual life
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