Abstract
Objective To investigate the impact of hyponatremia on the short-term prognosis in patients with acute ST-elevation myocardial infarction(STEMI) treated with percutaneous coronary intervention (PCI). Methods The present study included 324 patients with acute STEMI treated with PCI within 12 hours after admission from March 2014 to May 2016. Patients were divided into three groups according to plasma sodium levels (Na+ ) at admission: group A with Na+ <130 mmol/L, group B with Na+ 130-134 mmol/L and group C with Na+ ≥135 mmol/L (normal plasma sodium level). Clinical data and biochemical variables were compared among the three groups. Logistic regression analysis was used to examine the correlation between plasma sodium levels and short-term prognosis. Results There were significant differences in age, fasting glucose, NT-proBNP, LVEF (left ventricular ejection fraction) and hsCRP (high sensitive C-reactive protein) among the three groups(P<0.05). The mortality in group A was obviously higher than that in Group B (20.0% vs. 6.3%, P<0.05) and in group C (20.0% vs. 6.0%, P<0.05). In addition, there were significant differences in rates of cardiogenic shock and acute renal failure among three groups. Logistic regression analysis showed that old age, low LVEF and hyponatremia were independent risk factors for 30-day mortality (P<0.05). Compared with group B, patients in group A had significantly high risks of death (OR=3.058, 95%CI: 1.339-4.358, P=0.003), suggesting that the high risk of 30-day mortality associated with the severity of hyponatremia. Conclusions At admission, the hyponatremia in patients with acute STEMI treated with PCI is an independent risk factor for 30-day mortality, and prognosis worsens with the severity of hyponatremia. Key words: Hyponatremia; Acute ST-elevation myocardial infarction; Percutaneous coronary intervention; Short-term prognostic impact
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