Abstract
Materials and methods Ninety Saudi patients with acute coronary syndrome who underwent coronary angioplasty with drug eluting stents were consecutively enrolled in Prince Sultan Cardiac Center, Buraidah. Patients received clopidogrel as per usual dose of 300mg loading (about 4 days prior to procedure) and 75mg per day as maintenance dose. Two blood samples were withdrawn from each patient. DNA was extracted by [MagNAPure LC,Roche, Germany]. CYP2C19 and Genotyping for *1, *2 and *3 was conducted by real-time PCR [Roche Molecular Biochemicals, Mannheim, Germany]. Platelet function testing was carried out using (Verify Now P2Y12) and all the in-hospital clinical events were monitored for patients.
Highlights
Clopidogrel is a widely used oral, antiplatelet agent of thienopyridine class used to inhibit thrombosis following drug eluting stent (DES) placement [1]
Materials and methods Ninety Saudi patients with acute coronary syndrome who underwent coronary angioplasty with drug eluting stents were consecutively enrolled in Prince Sultan Cardiac Center, Buraidah
Platelet function testing was carried out using (Verify P2Y12) and all the in-hospital clinical events were monitored for patients
Summary
Clopidogrel is a widely used oral, antiplatelet agent of thienopyridine class used to inhibit thrombosis following drug eluting stent (DES) placement [1]. The variability of response (platelet function testing) to clopidogrel is multifactorial and genetic polymorphism has been known to be the main cause [2]
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