Abstract
Background: Diabetes may be more vulnerable to ambient air pollutants than healthy individuals. But, the risk factors that lead to susceptibility to air pollution in these diseases have not yet been identified. Aims: of this study was to examine the effect of air pollution on the pulmonary function test (PFT) and symptom. Methods: study recruited 400 type 2 diabetes and 465 healthy subjects who undergo into measurement of FVC and FEV1. Per cent predicted FEV1 and FVC (%FEV1 and %FVC respectively) for each subject were calculated. Particulate matter (PM10) concentrations at residence place of subjects were estimated using AERMOD dispersion model. The association between PM10 and %FEV1 and %FVC were investigated using linear regression models controlling for potential confounders, also effect of PM10 on chronic respiratory symptom was explored using logistic regression model. Result: There were no significant difference between % predicted value of PFT among diabetes and non-diabetes subject, and age group (P<0.05). Presence of diabetes was associated with odd of presences of current wheezing, allergy symptom, chest tightness, FEV1/FVC<70%, and physical diagnosed asthma and COPD. The adjusted odds of having dyspnea was 1.25 fold (95% C.I, 1.04- 1.50) greater in those exposed to 1SD (=61.28) µg/m3higher PM10 concentration. Higher exposure to PM10 concentration was significantly associated with lower %FVC. The size of effect on population mean %FVC was about 1.57% (0.20% to 2.94%) for 1SD µg/m3 increase in PM10 concentration. However, the effects were most marked in overweight, smoking, and older adult. Conclusions: PM10 exposure is associated with lower lung function independents of diabetes status. This study suggests that decline in exposure may significantly reduce disease manifest as dyspnea and impaired lung function. We conduct that higher BMI, smoking, and older age, are modifier of this association.
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