Abstract
Diabetes is one of the most challenging health problems in 21 century and insulin is the only effective treatment for type 1 diabetes mellitus and also an alternative treatment for type 2 diabetes mellitus in some conditions, and since the cost of insulin increased dramatically since 1990s, herbs and medicinal plants with a hypoglycemic effect become more popular especially in developing countries as a lower cost alternatives, Bauhinia varigta leaves alcoholic extract hypoglycemic activity were evaluated and compared to that of soluble insulin in alloxanized diabetic mice. HPLC analysis was applied to identify the presence of protiens similar to soluble insulin, also biological effects of the extract on sperm head morphology was evaluated. Bauhinia varigata alcoholic extract show a good hypoglycemic activity in compare to soluble insulin in diabetic mice, with possible presence of peptide similar to insulin, also it has a good effect in reducing risk of sperm head abnormalities.
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