Abstract
This study evaluated the histopathological effects of two different bone grafts, calcium triglyceride bone cement (CTBC) and chitosan, on the healing of experimental bone defects. Ninety-two Sprague Dawley male rats, with a weight of 240 ± 20 g, were used. Two experimental groups that consisted of 64 rats were divided into four subgroups due to the sacrification days, which were 7, 14, 30, and 60. After creating an 8-mm- long and 1-mm-wide cortico-cancellous bone defect in the right tibia of each rat, CTBC and chitosan were applied to the bone defects. In the main group, after creating the bone defects in the right tibias, we kept those empty to serve as the control group. We evaluated inflammation, foreign body reaction, necrosis, fibrosis, new bone formation, and the residual graft material at 7, 14, 30, and 60 days. In both the CTBC and chitosan groups, the new bone formation was higher than that in the control group, whereas foreign body reaction and residual graft material in the CTBC group and fibrosis in the chitosan group were significantly higher. After evaluating the results, both materials were found not to be very useful in the bone healing process. CTBC remained for a long time without being resorbed; it can be used as a placeholder in large bone defects, whereas the gel form of chitosan cannot be utilized for this purpose because it was resorbed in the first 7 days.
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