Abstract
Limited studies on whole slide imaging (WSI) in surgical neuropathology reported a perceived limitation in the recognition of mitoses. This study analyzed and compared the inter- and intra-observer concordance for atypical meningioma, using glass slides and WSI. Two neuropathologists and two residents assessed the histopathological features of 35 meningiomas—originally diagnosed as atypical—in a representative glass slide and corresponding WSI. For each histological parameter and final diagnosis, we calculated the inter- and intra-observer concordance in the two viewing modes and the predictive accuracy on recurrence. The concordance rates for atypical meningioma on glass slides and on WSI were 54% and 60% among four observers and 63% and 74% between two neuropathologists. The inter-observer agreement was higher using WSI than with glass slides for all parameters, with the exception of high mitotic index. For all histological features, we found median intra-observer concordance of ≥ 79% and similar predictive accuracy for recurrence between the two viewing modes. The higher concordance for atypical meningioma using WSI than with glass slides and the similar predictive accuracy for recurrence in the two modalities suggest that atypical meningioma may be safely diagnosed using WSI.
Highlights
IntroductionSerena Ammendola and Elena Bariani shared co-first authorship
Serena Ammendola and Elena Bariani shared co-first authorship.Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, ItalyDepartment of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, ItalyDepartment of Clinical Pathology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, SwedenDepartment of Pathology & Clinical Labs, University of Michigan, Ann Arbor, MI, USADepartment of Pathology, Wexner Medical Center, Ohio State University, Columbus, OH, USADivision of Pathology, Central Hospital Bolzano, Bolzano, Italy 7 ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy 8 Department of Diagnostics and Public Health, Polyclinic G.B
Light microscopy still represents the gold standard for histopathological diagnosis, whole slide imaging (WSI) systems, used to capture, transmit, and store digital images, have attracted growing interest
Summary
Serena Ammendola and Elena Bariani shared co-first authorship. Division of Pathology, Central Hospital Bolzano, Bolzano, Italy 7 ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy 8 Department of Diagnostics and Public Health, Polyclinic G.B. Rossi, P.le L.A. Scuro, 10, 37134 Verona, Italy. Traditional diagnostic pathology has been progressively influenced by technological advancement. Light microscopy still represents the gold standard for histopathological diagnosis, whole slide imaging (WSI) systems, used to capture, transmit, and store digital images, have attracted growing interest. Digital slides may have many advantages over glass slides such as easy archiving, research, teaching, and remote diagnosis or consultation [1,2,3,4]
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