Abstract
ObjectivesThis study was conducted in order to explore the value of histogram analysis of the intravoxel incoherent motion-kurtosis (IVIM-kurtosis) model in the diagnosis and grading of prostate cancer (PCa), compared with monoexponential model (MEM).Materials and MethodsThirty patients were included in this study. Single-shot echo-planar imaging (SS-EPI) diffusion-weighted images (b-values of 0, 20, 50, 100, 200, 500, 1,000, 1,500, 2,000 s/mm2) were acquired. The pathologies were confirmed by in-bore MR-guided biopsy. The postprocessing and measurements were processed using the software tool Matlab R2015b for the IVIM-kurtosis model and MEM. Regions of interest (ROIs) were drawn manually. Mean values of D, D*, f, K, ADC, and their histogram parameters were acquired. The values of these parameters in PCa and benign prostatic hyperplasia (BPH)/prostatitis were compared. Receiver operating characteristic (ROC) curves were used to investigate the diagnostic efficiency. The Spearman test was used to evaluate the correlation of these parameters and Gleason scores (GS) of PCa.ResultsFor the IVIM-kurtosis model, D (mean, 10th, 25th, 50th, 75th, 90th), D* (90th), and f (10th) were significantly lower in PCa than in BPH/prostatitis, while D (skewness), D* (kurtosis), and K (mean, 75th, 90th) were significantly higher in PCa than in BPH/prostatitis. For MEM, ADC (mean, 10th, 25th, 50th, 75th, 90th) was significantly lower in PCa than in BPH/prostatitis. The area under the ROC curve (AUC) of the IVIM-kurtosis model was higher than MEM, without significant differences (z = 1.761, P = 0.0783). D (mean, 50th, 75th, 90th), D* (mean, 10th, 25th, 50th, 75th), and f (skewness, kurtosis) correlated negatively with GS, while D (kurtosis), D* (skewness, kurtosis), f (mean, 75th, 90th), and K (mean, 75th, 90th) correlated positively with GS. The histogram parameters of ADC did not show correlations with GS.ConclusionThe IVIM-kurtosis model has potential value in the differential diagnosis of PCa and BPH/prostatitis. IVIM-kurtosis histogram analysis may provide more information in the grading of PCa than MEM.
Highlights
Prostate cancer (PCa) is the most common malignancy and the leading cause of cancer-related deaths among the elderly male [1]
We firstly evaluated the repeatability of mean values and histogram parameters derived from the intravoxel incoherent motion (IVIM)-kurtosis model
The Intraclass correlation coefficient (ICC) of histogram parameters seemed to be similar to the ICC of traditional mean value, which indicated that the histogram parameters may not have better repeatability than traditional mean value
Summary
Prostate cancer (PCa) is the most common malignancy and the leading cause of cancer-related deaths among the elderly male [1]. The accurate diagnosis and grading is critical in the appropriate treatment strategy and prognosis of PCa patients. Multiparametric MRI plays an important role in the detection, characterization, and staging of prostate cancer. The second edition of the Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) regarded diffusion-weighted imaging (DWI) as one of the two dominant sequences to evaluate PCa [2]. NonGaussian diffusion and blood microcirculation could both affect the characterization of PCa. Nowadays, DWI combined with various mathematical models has been gaining substantial interest as a possible tool to detect PCa, including intravoxel incoherent motion (IVIM) and kurtosis models
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
