Abstract
1 Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA; 2 Department of Gastroenterology, Affiliated Hospital, Zunyi Medical College, and Digestive Disease Institute of Guizhou Province, Zunyi 563003, China; 3 Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303, USA
Highlights
Studies over the last several decades have gradually revealed the critical involvement of calcium, especially its ionic form (Ca2+), in every aspect of life forms on earth
Numerous functions have been assigned to various Transient Receptor Potential (TRP) channels from temperature sensation to stress response to many different environmental challenges (Nilius and Owsianik, 2011; Julius, 2013; Ong et al, 2014)
The second wave was the consecutive identification of STIM (Liou et al, 2005; Zhang et al, 2005) and Orai (Feske et al, 2006; Vig et al, 2006; Zhang et al, 2006), an endoplasmic reticulum (ER) Ca2+ sensor and its channel partner on the plasma membrane, respectively, which work together to carry out “store-operated” or capacitative Ca2+ entry
Summary
Some of them had appeared in this particular journal over the past decades, especially in the two previous special spotlight issues dedicated to Ca2+ Signaling (Science China Life Sciences, 2011 54 (8) and 2015 58 (1)). The highlights in recent years have included molecular identification of a large number of Ca2+-permeable channels that exert their functions on the plasma membrane and the membranes of intracellular organelles, such as the endoplasmic reticulum (ER), mitochondria, and endolysosomes.
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