Abstract
Previous work has established that CD24 is a costimulatory molecule for T-cell clonal expansion. Studies using CD24 −/− mice demonstrated that CD24 plays a critical role in the CD28-independent immune response against virus and soluble antigens. The role of CD24 on dendritic cells (DCs) has not been reported. Here, we compare the CD24 +/+ and CD24 −/− DCs in the induction of initial clonal expansion and elicitation of memory CD4 + T cells in vivo. Our results demonstrate that the CD24 expressed on DCs is essential neither for the induction of initial T-cell clonal expansion nor for elicitation of memory activity of primed T cells in vivo.
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