Abstract
Copyright: © 2012 Fang EF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The Health Benefits of Soybeans and Bowman-Birk Inhibitor Concentrate Evandro Fei Fang1,2*, Ho Him Leung3, Yuan Fang4 and Tzi Bun Ng1* 1School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 2Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA 3Department of Medicine, Imperial College London, UK 4School of Public Health, Anhui Medical University, China
Highlights
Soybean (Glycine max L.) is a common and widely-distributed crop, its different dietary products are highly welcomed, especially to those living in the Orient [1,2]
Many medicinal components exist in soybean, such as lectins [3], Kunitz-type trypsin inhibitors [4,5,6], glyceollins [7], defensins [8], and Bowman-Birk inhibitor (BBI) and its isoforms [9,10], etc
The first study traced back to 1946 when Dr Donald Bowman isolated an inhibitor different from the soybean Kunitz trypsin inhibitors, and its further purification and characterization was accomplished by Dr Yehudith Birk
Summary
Soybean (Glycine max L.) is a common and widely-distributed crop, its different dietary products are highly welcomed, especially to those living in the Orient [1,2]. Many medicinal components exist in soybean, such as lectins [3], Kunitz-type trypsin inhibitors (named under its pioneer investigator Moses Kunitz) [4,5,6], glyceollins [7], defensins [8], and Bowman-Birk inhibitor (BBI) and its isoforms [9,10], etc. The first study traced back to 1946 when Dr Donald Bowman isolated an inhibitor different from the soybean Kunitz trypsin inhibitors, and its further purification and characterization was accomplished by Dr Yehudith Birk. In recognition of their pioneer work on this protein, Frattali in 1969 recommended to name it ‘Bowman-Birk inhibitor’ [11]. In addition to Bowman-Birk groups, the soybean Kunitztype inhibitors are in the limelight, details of their biochemical characteristics, sequences, structures, and medicinal activities are shown elsewhere [4,5,14,15]
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