Abstract
A clonal line of rat glial cells (C 6) that produces the brain-specific protein, S-100, has been successfully adapted to grow in a serumless, chemically-defined medium without loss of its differentiated function. The results of nutritional studies of these adapted cells (C 6s) emphasize the importance of determining the individual requirements of different cell lines for their optimal growth and function. These optimal conditions, which have yet to be completely determined for C 6s cells, do include an absolute requirement for iron. Differences in patterns of growth and fatty acid composition are observed between the parent and adapted cell lines. Growth-promoting factors are produced by C 6s cells, the characterization of which could be important to the understanding of cellular growth and control processes. The ability of functional cells to grow in a serumless medium should simplify study of the nature and control of some of the complex biochemical functions of cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
