Abstract
The storage of liver glycogen in 7 obese fasting subjects was assessed by observing the response of peripheral blood glucose to the intravenous injection of glucagon. Three subjects who were receiving liberal diets prior to the study showed a subnormal response within the first 4 days of total food deprivation. As the fast continued, the rise in peripheral blood sugar was gradually restored. During a second fast, these same subjects maintained a normal blood sugar response to glucagon. Another group of 4 subjects who had been on restricted diets prior to the study maintained their blood sugar response to glucagon during a similar fasting regimen. These observations indicate that in prolonged fasting or in periods of restricted dietary intakes, glycogen formation and gluconeogenesis are enhanced following a brief period of glycogen depletion.
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