Abstract
Rats of 18 genotypes derived from the Roman selected strains were tested for inhibition of feeding due to novelty (hyponeophagia) in the absence or presence of 1 mg/kg diazepam. The resulting data from three behavioral indices were subjected to the Hayman [(1954). Biometrics10:235–244], variance/covariance, Mendelian cross, and single-test cross analyses. Additive genetic variation, directional dominance for high neophobia, and some nonallelic interaction were detected. The genetic architecture of the separate behavioral indices, and its modification in the drugged subjects, was discussed in relation to evolutionary adaptation and the anxiolytic and appetite-enhancing actions of the drug.
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