Abstract
The formation of metabolic intermediate (MI) complexes from norbenzphetamine and N-hydroxyamphetamine occurs at similar rates in phenobarbital-induced rat and rabbit liver microsomes. However, in intact tissues (in vivo and in isolated perfused organs) MI complexes from these compounds are only formed in the lung. For all microsomal fractions and intact lung tissue more cytochrome P-450 forms a complex with N-hydroxyamphetamine as substrate than with norbenzphetamine.
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