Abstract
Recent molecular biological and genetic evidence demonstrates that the abnormal isoform of the host cell derived prion protein plays a central role in the transmission and development of spongiform encephalopathies (GAJDUSEK 1988; PRUSINER 1993). The prion protein undergoes a three-stage transition during disease development: cellular isoform of prion protein (PrPc)→scrapie isoform of prion protein (PrPSc)→prion protein (PrP27–30) (Prusiner 1993).KeywordsPrion ProteinPrion DiseaseConformational TransitionAmyloid FormationSecondary Structure ContentThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
