Abstract
The metabolic fate of the quinaldic acid moiety of quinaldylglycyltaurine has been studied in the rat, rabbit, and cat. This compound usually was excreted as quinaldic acid and quinaldylglycine by the rat, while the majority was eliminated unchanged or as quinaldylglycylglycine whether given orally or by subcutaneous injection to the cat. Quinaldic acid and quinaldylglycine, which have never been detected in cat urine, were found in the feces of two of the three cats. When quinaldylglycyltaurine was given orally to the rabbit, the major urinary metabolite was quinaldic acid, but if given by subcutaneous injection, it was excreted unchanged. Thus, the three species converted an oral dose of quinaldylglycyltaurine to quinaldic acid.
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