Abstract
Objective To investigate expressions of Ras homologue protein family A (RhoA)/RhoB and Rho-associated coiled coil Rho forming protein Kinase 1 (Rock1)/Rock2 in placenta tissues of severe preeclampsia (sPE) to clarify the molecular mechanisms of sPE. Methods The locations and expressions of RhoA/RhoB and Rock1/Rock2 between two groups were detected with immunohistochemistry. Results RhoA, RhoB, Rock1, and Rock2 were mainly distributed in cytoplasms of syncytiotrophoblasts, cytotrophoblast, endothelial cells, and endometrial stromal cells. Rock1 and Rock2 were less expressed in nucleus. The expression levels of RhoA, RhoB, Rock1, and Rock2 in sPE group were significantly higher than control group (P<0.05). Conclusions The signal pathway that consists of upstream RhoA /RhoB and downstream Rock1/Rock2 is up-regulated in sPE. It demonstrates that signal molecules including RhoA, RhoB, Rock1, and Rock2 may involve in the sPE pathogenesis through affecting shallow placenta implantation in preeclampsia, ischemia, hypoxia and apoptosis of trophoblasts, and injury of vascular endothelial cells and artery vasospasm. Key words: Pre-eclampsia/ME; Rho factor/ME; rho-associated kinases ME
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
